Analysis of APOE Genotypes and Cognitive Status in the Global Alzheimer's
Association Interactive Network
 
   Lead Investigator:    Scott Neu
   Institution      :    Laboratory of Neuro Imaging
   E-Mail           :    neu@loni.usc.edu
   Proposal ID      :    671


   Publications:


1  Neu SC, Pa J,  Kukull W, Beekly D,   Kusma A, Gangadharan P, Wang LS, Romero K, Arneric SP, Redolfi A, Orlandi D, Frisoni GB, Au R, Devine S, Auerbach S, Espinosa A, Boada M, Riuiz A, Johnson SC, Koscik R, Wang JJ, Hsu WC, Chen YL, Toga AW
   Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis
   Journal Article  JAMA Neurol,74:1178-1189,2017,PMC5759346

   PUBLISHED





   Proposal Description:
   We are conducting an analysis in which we are combining data from GAAIN data partners that have collected information on APOE genotype, clinical diagnosis, and other variables.  In particular, we are aiming to show that a significant number of subjects with the hard to find APOE e2 and e4 alleles can be obtained and studied through GAAIN.  We propose to aggregate NACC data with other GAAIN partner data and calculate APOE genotype frequencies by clinical diagnosis, subject sex, age, etc.